HBIGS Schools Schools Archive
“Molecular Mechanisms in Mitosis”
The HBIGS Winter School is aimed to PhD students interested in the molecular mechanisms governing mitosis. We will explore fundamental open questions in the field, including the roles of the signalling cascades in the segregation of subcellular components, the mechanisms and temporal control of molecular machines during mitosis, how asymmetry of stem cell divisions is modulated, and how misregulation of these processes lead to loss of cellular hierarchy and chromosome instability, which are hallmarks of several diseases, including cancer.
The goal of the Winter School is to bring together an interactive community with a shared interest in cell division to explore the latest developments and emerging methods in the field. We will select a small group of PhD students to foster productive interaction and discussion between scientists at different career stages.
Date: 4-7 Feb 2019
Venue: Heidelberg, Germany
Scientific Coordinators:
Sergio P. Acebrón (Centre for Organismal Studies; COS)
Gislene Pereira (Centre for Organismal Studies; COS)
“Regulatory RNAs in physiology, development and disease”
Over the past decade, we have seen a dramatic shift in our understanding of the role of ribonucleic acid (RNA) in the flow of genetic information in higher organisms. Based on data from small- and large-scale transcriptome analyses, we now know that a large portion of eukaryotic genomes is transcribed into RNAs that actually do not encode proteins, but rather exhibit vital and highly diverse regulatory functions. These include roles in chromosome segregation and stability, as well as fine-tuning of gene expression at the epigenetic, transcriptional and post-transcriptional levels. Unsurprisingly, this unexpected radical departure from the central dogma of molecular biology has sparked tremendous interest across all biological research areas and has already led to a flurry of exciting findings on how these different classes of regulatory RNAs are formed, how they act and to what extent they impact development, physiology and disease in eukaryotes. Concurrently, these new insights into the biology and function of non-coding RNAs have rapidly paved ways for a wealth of novel options for biotechnological exploitation, particularly for implementation of potent and safe therapeutical modalities based on deliberate RNA-mediated gene regulation in humans. Considering this unprecedented impact on biology and enormous potential for future medicine, we believe that a Summer School focused on the emerging role of regulatory RNAs in physiology, development and disease is both timely as well as of interest to a majority of the HBIGS students. In detail, we favor a broad focus spanning several relevant model organisms (plants, invertebrates, vertebrates as well as viruses), RNA classes (e.g., piRNAs, long non-coding RNAs, cellular or viral miRNAs, or ectopic shRNAs) and research areas (physiology, development, pathology as well as therapy). The panel of contacted speakers and the tentative program reflect this essential diversity.
Date: 4-7 Sep 2011
Venue: Boppard, Germany
Organizers:
Alexis Maizel (Center for Organismal Studies; COS)
Dirk Grimm (Dept. of Infectious Diseases/BioQuant)
“Cell Cycle Regulation”
Participants of the Summer School are PhD students and lecturers on selective topics of cell cycle regulation (Cyclin-Dependent Kinases (CDKs), Mitotic Kinases, Centromere Biology, Centrosome Biology, Spindle Assembly Pathways, Regulation of DNA Replication, Chromosome Segregation /APC, Spindle Assembly Checkpoint, DNA Damage Checkpoints, Mass spec of Mitotic Regulators). Each invited scientist was invited to bring along one PhD student from his/her laboratory.
Date: 18-21 May 2009
Venue: Boppard, Germany
Organizers:
Elmar Schiebel (Center for Molecular Biology; ZMBH)
Olver Gruss (Center for Molecular Biology; ZMBH)
Gislene Pereira (Centre for Organismal Studies; COS)